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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK12
All Species:
17.27
Human Site:
Y72
Identified Species:
31.67
UniProt:
P53778
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53778
NP_002960.2
367
41940
Y72
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
Chimpanzee
Pan troglodytes
Q95NE7
360
41475
L72
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
Rhesus Macaque
Macaca mulatta
XP_001112462
367
41940
Y72
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
Dog
Lupus familis
XP_848658
287
32890
G33
Y
L
V
M
P
F
M
G
T
D
L
G
K
L
M
Cat
Felis silvestris
Mouse
Mus musculus
O08911
367
42025
Y72
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
Rat
Rattus norvegicus
Q63538
367
41967
Y72
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509537
374
42522
L73
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
Chicken
Gallus gallus
XP_001233062
310
36087
P56
N
G
F
Y
L
V
M
P
F
M
G
T
D
L
S
Frog
Xenopus laevis
P47812
361
41700
L73
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
Zebra Danio
Brachydanio rerio
O42376
363
41952
L73
A
K
R
A
Y
R
E
L
R
L
L
K
H
M
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61443
365
42080
L72
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17446
377
43900
Y80
I
I
H
A
R
R
T
Y
R
E
L
R
L
L
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q96TL5
358
41225
K72
Y
R
E
L
K
L
L
K
H
L
R
H
E
N
V
Conservation
Percent
Protein Identity:
100
61.8
99.1
74.1
N.A.
92.6
93.7
N.A.
66.5
65.4
60.2
67.8
N.A.
56.9
N.A.
54.6
N.A.
Protein Similarity:
100
77.6
99.1
75.7
N.A.
95.9
96.1
N.A.
77.5
76.5
76.5
81.7
N.A.
73.8
N.A.
72.1
N.A.
P-Site Identity:
100
26.6
100
20
N.A.
100
100
N.A.
20
13.3
26.6
33.3
N.A.
20
N.A.
60
N.A.
P-Site Similarity:
100
40
100
26.6
N.A.
100
100
N.A.
40
13.3
40
46.6
N.A.
33.3
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
46.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
65.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
39
0
0
54
0
0
31
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
8
% D
% Glu:
31
0
8
0
0
0
39
0
0
39
0
0
8
0
0
% E
% Phe:
0
0
39
0
0
8
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
8
0
0
8
8
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
8
0
0
8
39
0
0
% H
% Ile:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
39
0
0
39
0
0
8
0
0
0
39
8
0
54
% K
% Leu:
0
39
0
8
8
8
8
39
8
47
85
0
39
54
0
% L
% Met:
0
0
0
8
0
0
16
0
0
8
0
0
0
39
8
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
8
39
0
8
77
0
0
70
0
8
39
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
0
24
0
0
8
0
8
0
0
8
0
0
0
% T
% Val:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
0
8
39
0
0
39
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _